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Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 160-188 doi: 10.1007/s11684-018-0629-9

Abstract: Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defectsto address the unmet need for bone augmentation and skeletal repair.Effective therapies for bone regeneration primarily require the coordinated combination of innovativeregeneration.regeneration.

Keywords： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: Clinical imperatives for the reconstruction of jaw bone defects or resorbed alveolar ridge require newtherapies or procedures instead of autologous/allogeneic bone grafts.cell science and tissue engineering technology, is considered as an ideal alternative strategy for boneregeneration.The preclinical animal models for bone regeneration and the key translational points to clinical success

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

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Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 189-201 doi: 10.1007/s11684-018-0664-6

Abstract: The review further exemplifies their applications for bone tissue regeneration.

Keywords： hybrid polymer     bone regeneration     tissue engineering     biomaterials    

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Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 470-483 doi: 10.1007/s11705-012-1217-1

Abstract: excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high boneMacroporous scaffolds made from BGs are in high demand for bone regeneration because they can stimulatevascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues.progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for boneregeneration.

Keywords： bioactive glass     biopolymer     bone regeneration     macroporous scaffolds     tissue engineering    

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Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal

Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 512-518 doi: 10.1007/s11783-011-0372-9

Abstract: Fe-Mn binary oxide incorporated into porous diatomite (FMBO-diatomite) was prepared in situ and regenerated in a fixed-bed column for arsenite [As(III)] and arsenate [As(V)] removal. Four consecutive adsorption cycles were operated under the following conditions: Initial arsenic concentration of 0.1 mg·L , empty bed contact time of 5 min, and pH 7.0. About 3000, 3300, 3800, and 4500 bed volumes of eligible effluent (arsenic concentration≤0.01 mg·L ) were obtained in four As(III) adsorption cycles; while about 2000, 2300, 2500, and 3100 bed volumes of eligible effluent were obtained in four As(V) adsorption cycles. The dissection results of FMBO-diatomite fixed-bed exhibited that small amounts of manganese and iron were transferred from the top of the fixed-bed to the bottom of the fixed-bed during As(III) removal process. Compared to the extremely low concentration of iron (<0.01 mg·L ), the fluctuation concentration of Mn in effluent of the As(III) removal column was in a range of 0.01–0.08 mg·L . The release of manganese suggested that manganese oxides played an important role in As(III) oxidation. Determined with the US EPA toxicity characteristic leaching procedure (TCLP), the leaching risk of As(III) on exhausted FMBO-diatomite was lower than that of As(V).

Keywords： arsenic     adsorption     filtration     regeneration     fixed-bed    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: definite role in the development of acute myeloid leukemia (AML) and emphasize its associations with bonefunctional analyses indicated that FGF13 was not associated with AML driver mutations but was related to boneOverall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to the bone

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration

Bin Yu, Xiaosong Gu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 131-137 doi: 10.1007/s11684-018-0642-z

Abstract: The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowing axons to follow, and, often by combining stem cell transplantation, to enable the local environment in the growth-supportive direction. Manipulations, such as the modulation of PTEN/mTOR pathways, can also enhance intrinsic CNS axon regrowth after injury. Given the complex pathophysiology of SCI, combining biomaterial scaffolds and genetic manipulation may provide synergistic effects and promote maximal axonal regrowth. Future directions will primarily focus on the translatability of these approaches and promote therapeutic avenues toward the functional rehabilitation of patients with SCIs.

Keywords： spinal cord injury     biomaterial     extrinsic barrier     intrinsic regeneration capacity    

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Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning

SHI Mingheng, DU Bin, ZHAO Yun

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 85-90 doi: 10.1007/s11708-007-0008-8

Abstract: In this paper regeneration and energy storage characteristics were studied theoretically and experimentallyTwo criterion equations for heat and mass transfer in the regeneration process were obtained.The main factors that influence the regeneration process were analyzed.

Keywords： desiccant air-conditioning     regeneration process     air-conditioning system     energy     regeneration    

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Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 522-526 doi: 10.1007/s11684-016-0485-4

Abstract: Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permissionAutologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, andAfter the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient&rsquo

Keywords： autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

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Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0717-z

Abstract: Bone grinding is an essential and vital procedure in most surgical operations.results showed that U-NJMC provides a novel approach for clinical surgical micro-grinding of biological bone

Keywords： micro-grinding     biological bone     ultrasonic vibration (UV)     nanoparticle jet mist cooling (NJMC)     grinding    

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Evaluation of power regeneration in primary suspension for a railway vehicle

Ruichen WANG, Zhiwei WANG

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 2,   Pages 265-278 doi: 10.1007/s11465-019-0571-9

Abstract: To improve the fuel economy of rail vehicles, this study presents the feasibility of using power regenerating dampers (PRDs) in the primary suspension systems of railway vehicles and evaluates the potential and recoverable power that can be obtained. PRDs are configured as hydraulic electromagnetic-based railway primary vertical dampers and evaluated in parallel and series modes (with and without a viscous damper). Hydraulic configuration converts the linear behavior of the track into a unidirectional rotation of the generator, and the electromagnetic configuration provides a controllable damping force to the primary suspension system. In several case studies, generic railway vehicle primary suspension systems that are configured to include a PRD in the two configuration modes are modeled using computer simulations. The simulations are performed on measured tracks with typical irregularities for a generic UK passenger route. The performance of the modified vehicle is evaluated with respect to key performance indicators, including regenerated power, ride comfort, and running safety. Results indicate that PRDs can simultaneously replace conventional primary vertical dampers, regenerate power, and exhibit desirable dynamic performance. A peak power efficiency of 79.87% is theoretically obtained in series mode on a top-quality German Intercity Express track (Track 270) at a vehicle speed of 160 mile/h (~257 km/h).

Keywords： railway vehicle     primary damper     power regeneration     ride comfort     running safety    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationpossibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 3,   Pages 300-306 doi: 10.1007/s11783-009-0031-6

Abstract: Since the solubilization of meat and bone meal (MBM) is a prerequisite in many MBM disposal approaches

Keywords： thermochemical pretreatment     meat and bone meal     solid reduction     solid solubilization     methane production    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced lifeWe further delineate an informative cancer bone metastatic cascade based on evidence from recent studiesand point out the main factors responsible for the tumor-associated disruption of bone homeostasis and

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: expressed mRNA in chronic kidney disease (CKD) to predict putative microRNA (miRNA) in CKD–mineral bone

Keywords： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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Title Author Date Type Operation

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Journal Article

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

Journal Article

Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

Journal Article

Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal

Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration

Bin Yu, Xiaosong Gu

Journal Article

Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning

SHI Mingheng, DU Bin, ZHAO Yun

Journal Article

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Journal Article

Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

Journal Article

Evaluation of power regeneration in primary suspension for a railway vehicle

Ruichen WANG, Zhiwei WANG

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article